Police said 53-year-old Michael Garcia was taken into custody following the crash that happened around 10:30 p.m. on Thursday at the intersection of South Flores Street and Congress Avenue.
Investigators said the victim, identified as 33-year-old Glenn Cabatbat, was riding his motorcycle when Garcia suddenly made a left-hand turn, cutting him off and colliding with the bike. Cabatbat was killed instantly, according to investigators.
Police said Garcia stopped after the crash and attempted to help. However, investigators later charged him with intoxication manslaughter.
The case remains an active investigation.